Effect Of Psyllium Seed Husk On Anthropometric Parameters, Lipid And Electrolyte Profile In Hypercholesterolemia Induced Rats
By: Arfa Ibtisham (2015-VA-24)
| Dr. Imtiaz Rabbani.
Contributor(s): Dr. Khalid Abdul Majeed | Dr. Sanaullah Iqbal.
Material type: 
BookPublisher: 2017Description: 49p.Subject(s): PhysiologyDDC classification: 2867-T Dissertation note: Hypercholesterolemia is characterized by higher level of bad cholesterol in blood which shoots up the risk factor for cardiovascular diseases, hyperlipidemia, oxidative stress, weight gain and other metabolic disorders. Modern way of life is the reason to elevate these metabolic syndromes that lead to increased mortality rate. Psyllium husk is helpful in improving anthropometric parameters, high lipid profile, glucose level, appetite, oxidative status, hypertension and maintains liver and renal physiology. The effective use of this drug was for weight loss to control obesity.
The consumption of psyllium husk may lead to hypocholesterolemia, reduced body weight, oxidative stress and biological profile in rats. Twenty four male Wistar rats were taken and divided into four groups. Group-I (negative control) fed chow diet Group-II (positive control) was given chow diet mixed with 10g cholesterol for 42 days. Group-III (treatment group) hypercholesterolemic rats were fed with 5g psyllium husk for 21 days. Group-IV (treatment group) hypercholesterolemic rats were fed with 10g psyllium husk for 21 days. Blood samples were collected at the end of six weeks of study. Anthropometric parameters, organs weight, Lipid profile (TC, TC, LDL, HDL, Atherogenic index), glucose, oxidant and antioxidant levels, electrolytes, hepatic (AST, ALT) and renal (blood urea nitrogen, urea) functions (in blood liver and kidney) were studied. Data were analyzed using one way ANOVA on SPSS. Differences between the groups were compared by Duncan’s Multiple Range Test. Differences were considered significant at P < 0.05.
Anthropometric measurements, organs weight, lipid profile, glucose,urea and blood urea nitrogen showed significantly results, while,TG, atherogenic index ,electrolytes, oxidant and anti-oxidant ALT and AST showed no significantly values.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 2867-T (Browse shelf) | Available | 2867-T |
Hypercholesterolemia is characterized by higher level of bad cholesterol in blood which shoots up the risk factor for cardiovascular diseases, hyperlipidemia, oxidative stress, weight gain and other metabolic disorders. Modern way of life is the reason to elevate these metabolic syndromes that lead to increased mortality rate. Psyllium husk is helpful in improving anthropometric parameters, high lipid profile, glucose level, appetite, oxidative status, hypertension and maintains liver and renal physiology. The effective use of this drug was for weight loss to control obesity.
The consumption of psyllium husk may lead to hypocholesterolemia, reduced body weight, oxidative stress and biological profile in rats. Twenty four male Wistar rats were taken and divided into four groups. Group-I (negative control) fed chow diet Group-II (positive control) was given chow diet mixed with 10g cholesterol for 42 days. Group-III (treatment group) hypercholesterolemic rats were fed with 5g psyllium husk for 21 days. Group-IV (treatment group) hypercholesterolemic rats were fed with 10g psyllium husk for 21 days. Blood samples were collected at the end of six weeks of study. Anthropometric parameters, organs weight, Lipid profile (TC, TC, LDL, HDL, Atherogenic index), glucose, oxidant and antioxidant levels, electrolytes, hepatic (AST, ALT) and renal (blood urea nitrogen, urea) functions (in blood liver and kidney) were studied. Data were analyzed using one way ANOVA on SPSS. Differences between the groups were compared by Duncan’s Multiple Range Test. Differences were considered significant at P < 0.05.
Anthropometric measurements, organs weight, lipid profile, glucose,urea and blood urea nitrogen showed significantly results, while,TG, atherogenic index ,electrolytes, oxidant and anti-oxidant ALT and AST showed no significantly values.
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